| Validation of cured heart failure biomarkers | HMC000044 | proteomics, microarrays, biomarkers, heart failure, diagnosis, heart function recovery | 39 | heart disease, end-stage organ failure, heart transplant | Stable Heart Function, Unstable Heart Function | Plasma, Serum, Whole Blood | Proteomics, Transcriptomics | Expression Profiling by Array (Affymetrix HG U133 plus 2), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS) |
| Better biomarkers for transplantation | HMC000048 | cardiac transplant, renal transplant, liver transplant, acute rejection, chronic rejection, diagnostic, prognostic, biomarkers | 767 | heart transplant, kidney transplant, liver transplant, end-stage organ failure | Solid organ transplant recipients | Buffy Coat, Heart biopsy, Kidney biopsy, Liver biopsy, Plasma, Serum, Urine, Whole Blood | Metabolomics, Proteomics, Transcriptomics | Expression Profiling by Array (Affymetrix HG U133 plus 2), Expression profiling by array (Affymetrix HU Gene 1.1 ST), Isobaric tag for relative and absolute quantitation (iTRAQ), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS), Nuclear Magnetic Resonance spectroscopy (NMR) |
| Diagnostic Biomarkers for Improved Heart Failure Management | HMC000050 | proteomics, transciptiomics, diastolic heart failure, systolic heart failure, preserved ejection fraction, reduced ejection fraction, biomarkers | 261 | diastolic heart failure, systolic heart failure | Heart Failure, Controls | Buffy Coat, Plasma, Serum, Urine, Whole Blood | Proteomics, Transcriptomics | Expression profiling by array (Affymetrix HU Gene 1.1 ST), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS) |
| Biomarker Discovery in Acute Heart Failure | HMC000051 | proteomics, transciptiomics, acute heart failure, biomarkers, mechanical circulatory support, ventricular assist device | 13 | acute heart failure | Acute heart failure | Buffy Coat, Plasma, Serum, Urine, Whole Blood | Proteomics | Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS) |
| Clinical Implementation of Diagnostic Biomarker Assays in Heart and Kidney Transplantation | HMC000052 | heart transplantation, kidney transplantation, proteomics, transcriptomics, acute rejection, diagnosis, prognosis, biomarkers | 692 | heart transplant, kidney transplant, end-stage organ failure | Organ transplant recipients, Non-transplant controls | Buffy Coat, Heart biopsy, Plasma, Serum, Whole Blood | Proteomics, Transcriptomics | Expression Profiling by Array (Affymetrix HG U133 plus 2), Expression profiling by array (Affymetrix HU Gene 1.1 ST), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS) |
| The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity | HMC000065 | FOXL2 transcription factor, adult-type granulosa cell tumors, ovary, cancer, epigenomics | 1 | cancer, granulosa cell tumor | SVOG3e cell line, KGN cell line | Ovary | Epigenomics, Genomics, Proteomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS), RNA-seq, Transcription Factor ChIP-seq |
| Dysferlinopathy | HMC000086 | limb-girdle muscular dystrophy 2B, LGMD2b, limb girdle muscular dystrophy type R2, LGMDR2, Miyoshi Myopathy type 1, MMD1, dysferlinopathy | 75 | autosomal recessive limb-girdle muscular dystrophy type 2B, dysferlinopathy, limb-girdle muscular dystrophy | Limb-girdle muscular dystrophy 2B, Validation cohort from COS study, healthy age-matched controls | Plasma, Whole Blood | Proteomics, Transcriptomics | Affymetrix GeneChip miRNA 3.1, Expression Profiling by Array (Affymetrix HG U133 plus 2), Isobaric tag for relative and absolute quantitation (iTRAQ) |
| BQC19: Biobanque québécoise de la COVID-19 | HMC000096 | COVID-19, biobank, multiomics, longitudinal study | 6272 | COVID-19, severe COVID-19, non-severe COVID-19, long COVID, critical COVID-19 | SARS-CoV-2 Positive patients, Mother and Child Centre, SARS-CoV-2 Negative patients | DNA, PBMC, Plasma, RNA, SARS-CoV-2 viral DNA, Serum | Genomics, Metabolomics, Proteomics, Transcriptomics | Genome-Wide Association Study (GWAS), Metabolon, Neutralizing antibodies against SARS-CoV-2, OLINK, RNA-seq, Roche Diagnostics, SARS-CoV-2 specific antibodies detected by ELISA, SomaLogic, Whole Genome Sequencing (WGS) |