| Integration of Environmental and Genomic Risk Factors to Predict Fibrotic Interstitial Lung Disease (fILD) Progression | HMC000049 | Genomics, Epigenomics, Air pollution | 1000 | interstitial lung disease | Canadian Registry for Pulmonary Fibrosis (CER-PF) | Air, DNA | Epigenomics, Exposomics, Genomics | DNA Methylation: Infinium Methylation EPIC array, Environment, Whole Genome Shotgun sequencing, methylation Quantitative Trait Loci (meQTLs) | Genome British Columbia |
| DNA Methylation Analysis Of A Subset Of Children From The Canadian Asthma Primary Prevention Study | HMC000054 | Asthma, DNA methylation | 632 | allergic disease, asthma | Children with DNA methylation data, Mothers with DNA methylation data | Cord Blood, Whole Blood | Epigenomics | Targeted DNA methylation Sequencing: Illumina TruSeq Methyl Capture EPIC sequencing library | Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) |
| Epigenomic Dynamics of Facioscapulohumeral Muscular Dystrophy (FSHD) | HMC000058 | FSHD, muscle disorder, epigenomics | 2 | facioscapulohumeral muscular dystrophy | Cell line '54-6' - Myogenic Cells - Healthy, Cell line 'K8' - Fibro-Adipogenic Progenitor Cells - FSHD1, Cell line 'K4' - Myogenic Cells - Healthy, Cell line '54-12' - Fibro-Adipogenic Progenitor Cells - FSHD1 | In vitro differentiated myotube | Epigenomics, Transcriptomics | ChIP-seq for H2AK119Ub1 (histone modification), ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me2 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), RNA-seq | SOLVE-FSHD |
| Epigenetic and Transcriptional Profiling of Adult and Neonatal Naive CD4+ T Cells | HMC000059 | epigenetic, T cell, immune system, cord blood, PBMC | 6 | healthy | Adult Naive CD4+ T cells (n=3), Neonatal Naive CD4+ T cells (n=3) | Purified Immune Cells (T Cells) | Epigenomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), RNA-seq | Genome British Columbia, Canadian Institutes of Health Research (CIHR), Genome Canada |
| Epigenomic Profiling of Normal Human Breast Mammary Tissue Derived From Reduction Mammoplasties | HMC000060 | epigenetics, epigenomics, breast, mammary | 8 | healthy | Normal Breast Tissue | Breast | Epigenomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), RNA-seq | Genome Canada, Canadian Institutes of Health Research (CIHR) |
| Targeting SS18::SSX Biology In Synovial Sarcomagenesis | HMC000061 | Synovial Sarcoma, Epigenetics, cancer, fusion oncoprotein | 53 | cancer, synovial sarcoma | Synovial Sarcoma Diagnosis, Non-Synovial Sarcoma Diagnosis | BCOR-rearranged sarcoma, Synovial sarcoma | Epigenomics, Genomics, Transcriptomics | ChIP-seq for H2AK119Ub1 (histone modification), ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me2 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), Duet evoC (genome, 5mc, 5hm sequencing), RNA-seq, Single Cell Chromatin Accessibility Sequencing (scATAC), Whole Genome Sequencing (WGS) | Canadian Institutes of Health Research (CIHR), Terry Fox Research Institute, Marathon of Hope Cancer Centres Networks |
| Epigenomic Programming in Early Fetal Brain Development | HMC000063 | fetal brain, twins, epigenomics, epigenetic, neurospheres | 4 | healthy | | Brain, Neurospheres | Epigenomics, Transcriptomics | ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), MRE-seq, MeDIP, MicroRNA-seq, RNA-seq | Genome British Columbia, NIH, Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC), Canadian Institutes of Health Research (CIHR) |
| The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity | HMC000065 | FOXL2 transcription factor, adult-type granulosa cell tumors, ovary, cancer, epigenomics | 1 | cancer, granulosa cell tumor | SVOG3e cell line, KGN cell line | Ovary | Epigenomics, Genomics, Proteomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), Multiple Reaction Monitoring (MRM) with Mass Spectrometry (MS), RNA-seq, Transcription Factor ChIP-seq | Terry Fox Research Institute |
| Simultaneous Genetic and Epigenetic Analysis with Biomodal Duet Multiomics Solution +modC | HMC000077 | multiomics; genotype; DNA methylation; cell-free DNA; allelic-specific methylation | 8 | cancer, synovial sarcoma | Biomodal Hirst pilot project | Synovial sarcoma, cfDNA | Epigenomics, Genomics | biomodal(duet+modC) | biomodal, illumina |
| Epigenetic Profiling of Human Normal Hematopoietic Stem Cells from Umbilical Cord Blood | HMC000078 | umbilical cord blood, fetal blood, primary cells, stem cells, epigenomics, bivalent promoter, nucleosome density | 6 | normal | Normal Umbilical Cord Blood Cells | Purified common myeloid progenitor (CMP) cells, Purified cord blood CD34+CD38- cells, Purified erythroid cells, Purified granulocyte-monocyte progenitor (GMP) cells, Purified megakaryocyte-erythrocyte progenitor (MEP) cells, Purified monocyte cells | Epigenomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), RNA-seq | Genome British Columbia, Terry Fox Research Institute, Canadian Institutes of Health Research (CIHR) |
| Epigenetic Profiling of Human Acute Myeloid Leukemia Primary Samples | HMC000091 | AML, epigenomics, cancer, leukemia, bone marrow | 9 | acute myeloid leukemia | Acute Myeloid Leukemia (AML) | Bone Marrow Mononuclear Cells | Epigenomics, Transcriptomics | ChIP-seq for H3K27ac (histone modification), ChIP-seq for H3K27me3 (histone modification), ChIP-seq for H3K36me3 (histone modification), ChIP-seq for H3K4me1 (histone modification), ChIP-seq for H3K4me3 (histone modification), ChIP-seq for H3K9me3 (histone modification), DNA Methylation: WGBS (Whole Genome Bisulfite Sequencing), RNA-seq | Genome Canada, Terry Fox Research Institute, Canadian Institutes of Health Research (CIHR) |
| Mining The Infant Gut Microbiota To Predict And Prevent Asthma: Data From The CHILD Cohort Study | HMC000097 | | 3621 | childhood-onset asthma | Definite Asthma, No Asthma, Possible Asthma | Breast Milk, Cord Blood, Cord blood mononuclear cells (CBMC), DNA, Dust, PBMC, Plasma, RNA, Saliva/Buccal swabs, Serum, Stool, Swab (nasal), Urine, Whole Blood | Epigenomics, Genomics, Hormones, Lipidomics, Metabolomics, Microbiomics, Proteomics | Amplicon Sequencing (16S), Amplicon Sequencing (ITS), DNA Methylation: Infinium Methylation EPIC array, Gas liquid chromatography, Genotyping data using the HumanCoreExome BeadChip (Illumina), High performance liquid chromatography, Kits precoated with the antibody to each hormone purchased from Mesoscale Discovery, OLINK, Shotgun Metagenomic DNA Sequencing, Specific gravity corrected concentrations (nanograms/ml) of phthalate ester metabolites, Targeted liquid chromatography with tandem mass spectrometry (LC-MS/MS) assays, Targeted nuclear magnetic resonance (NMR) | Genome British Columbia, AllerGen Networks of Centres of Excellence, Canadian Institutes of Health Research (CIHR), Genome Canada |
| Accelerated Epigenetic Aging Worsens Survival And Mediates Environmental Stressors In Fibrotic Interstitial Lung Disease | HMC000098 | Epigenetic age, Air pollution, Transplant free survival | 476 | interstitial lung disease | fILD | Buffy Coat | Epigenomics | DNA Methylation: Infinium Methylation EPIC array | Genome British Columbia, Boehringer Ingelheim |