Data Entry Maintenance

Metadata Commons Identifier

HMC000130

Project Title

Quantifying Intratumoral Biomarker Heterogeneity in Tubo-ovarian High-grade Serous Carcinoma to Optimize Clinical Translation

Project Description

<span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-family:BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">The Canadian Ovarian Experimental Unified Resource (COEUR) has created a cohort of 437 FFPE tissue specimens from 108 tubo-ovarian high-grade serous carcinoma (HGSC) patients to quantify Intra-Tumor Heterogeneity (ITH) across the anatomical sites and between primary and recurrence. We quantified the ITH of six clinically used immunohistochemical diagnostic and prognostic biomarkers (WT1, p53, p16, PR, CD8, and Ki67). Markers were stained on tissue microarrays and scored using a continuous or categorical interpretation of staining patterns.<span style="-webkit-text-stroke-width:0px;display:inline !important;float:none;font-family:BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif;font-size:16px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">Additional information: <ul><li><a href="https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.tfri.ca%2Fcoeur&data=05%7C02%7Cacarles%40genomebc.ca%7C4a79da5df7384acfdffd08de1e657848%7C7e7e9eba717948ba97600035e63cf1f3%7C0%7C0%7C638981618371902635%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=nyYDUroxBquasMBe24jjhOY9GeNLttSYwc14kUDnpyw%3D&reserved=0">https://www.tfri.ca/coeur</a> </li></ul>

Project Funder(s)

Terry Fox Research Institute, Ovarian Cancer Canada

Project Institution(s)

University of British Columbia, University of Montreal Hospital Center (CHUM), University of Calgary, University of Montreal

Project Investigator(s)

Aline Talhouk, Derek S Chiu, Liliane Meunier, Kurosh Rahimi, Cécile Le Page, Monique Bernard, Diane Provencher, David G Huntsman, Anne Marie Mes Masson, Martin Köbel

Data Access Request URL*

Keywords

tubo-ovarian high-grade serous carcinoma, intratumoral biomarker heterogeneity, ovarian, translational

Publication Link

https://pubmed.ncbi.nlm.nih.gov/39828752

Study Completed

Post to REACH BC Platform

Cohort Name

TFRI COEUR ITH Ovarian Cohort

Cohort Size

108

Disease/Condition Studied

high-grade serous ovarian carcinoma, cancer

Enrollment Time Window

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

patients diagnosed with HGSC

Patient Outcomes

Clinical Data Types Available

Time Course Data Points

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics