Data Entry Maintenance

Metadata Commons Identifier

HMC000111

Project Title

Epigenetic Mechanisms for The Development of Asthma

Project Description

<p>Asthma is a common chronic disorder that affects both children and adults and causes decreased quality of life for those who suffer from the illness and for their families. Asthma affects as many as 300 million people in the world and is the cause of 1 in every 250 deaths world-wide. There is a genetic predisposition to asthma but increasing evidence shows that environmental insults such as smoking exposure, pollution, viruses, and common allergens are involved in the development of asthma. This study is designed to see how these genetic and environmental factors interact to contribute to asthma. This knowledge could lead to preventative public health policies and/or new therapies.<br> </p><ul><li>Publication ‘<a href="https://pubmed.ncbi.nlm.nih.gov/24646526/">The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population</a>’ (PMID 24646526)</li></ul>

Project Funder(s)

Canadian Institutes of Health Research (CIHR)

Project Institution(s)

University of British Columbia (UBC)

Project Investigator(s)

Catherine Laprise, Denise Daley

Data Access Request URL*

Keywords

Epigenetic clock, Asthma, Allergies, DNA methylation, CpG

Publication Link

https://www.mdpi.com/2073-4425/14/9/1724

Study Completed

Cohort Name

Saguenay Lac Saint Jean

Cohort Size

1394

Disease/Condition Studied

childhood-onset asthma, asthma, allergic rhinitis

Enrollment Time Window

1997-2007

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

asthma

Patient Outcomes

Clinical Data Types Available

questionnaire, physician visit

Time Course Data Points

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics