Data Entry Maintenance

Metadata Commons Identifier

HMC000064

Project Title

Hypopharyngeal Head and Neck Squamous Cell Carcinoma (HNSCC) Gene Expression Profiling

Project Description

The following 3 publications describe a comprehensive large-scale gene expression analysis of well-defined stages of HNSCC tumour evolution in a precise head and neck site, the hypopharynx. <ul> <li><a rel="noopener" target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/14612907/">Lemaire et al., 2003</a> - https://pubmed.ncbi.nlm.nih.gov/14612907/ - A large-scale differential display comparison of hypopharyngeal HNSCCs against histologically normal tissue from the same patients.</li> <li><a rel="noopener" target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/14676830/">Cromer et al., 2004</a> - https://pubmed.ncbi.nlm.nih.gov/14676830/ - An Affymetrix microarray analysis that identified genes whose expression differs between hypopharyngeal tumours and normal tissues, as well as between tumours with similar initial stage and histopathological features but with different clinical outcomes</li> <li><a rel="noopener" target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/16261155/">Carles et al, 2006</a> - https://pubmed.ncbi.nlm.nih.gov/16261155/ - Integrative genomics and bioinformatics analysis of a large-scale differential display expression profiling (Lemaire et al., 2003) with a parallel Affymetrix microarrays study that used the same hypopharyngeal HNSCC samples (Cromer et al., 2004).</li> <li>https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2379</li> </ul> Links to Data Repositories: <ul> <li>GEO: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2379</li> <li>ArrayExpress: https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-GEOD-2379</li> </ul>

Project Funder(s)

Centre National de la Recherche Scientifique (CNRS), Hôpital Universitaire de Strasbourg, European Union (FP5), Fondation pour la Recherche Médicale

Project Institution(s)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre Paul Strauss

Project Investigator(s)

Bohdan Wasylyk, Olivier Poch, Joseph Abecassis

Data Access Request URL*

Keywords

oncogenomics, HNSCC, hypopharyngeal cancer

Publication Link

https://pubmed.ncbi.nlm.nih.gov/16261155/

Study Completed

Cohort Name

Hypopharyngeal Head and Neck Squamous Cell Carcinoma (HNSCC)

Cohort Size

187

Disease/Condition Studied

head and neck squamous cell carcinoma, cancer

Enrollment Time Window

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

hypopharyngeal tumours

Patient Outcomes

survival, lymph node involvement, local recurrence, metastasis

Clinical Data Types Available

Age, Sex, treatment after surgery, TNM stages (tumour, node, metastasis) based on the UICC criteria (Sobin and Wittekind, 1997),

Time Course Data Points

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics