Data Entry Maintenance

Metadata Commons Identifier

HMC000051

Project Title

Biomarker Discovery in Acute Heart Failure

Project Description

<span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">This project looked at patients with acute decompensated heart failure who may or may not receive a short-term assist device as treatment for their condition. Patients who are on <span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">specific medications for their condition were enrolled into the study while they were in hospital. Blood and urine samples were collected at time of enrollment. The goal of the study was to <span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">identify biomarkers to determine whether they should put patients on a short-term assist device, implantable assist device or not to use either.

Project Funder(s)

PROOF Centre of Excellence

Project Institution(s)

University of British Columbia, PROOF Centre of Excellence

Project Investigator(s)

Annemarie Kaan, Bruce McManus, Andrew Ignaszewski, Krishnan Ramanathan, Anna Meredith, Ellamae Stadnick, Samuel Lichtenstein

Data Access Request URL*

Keywords

proteomics, transciptiomics, acute heart failure, biomarkers, mechanical circulatory support, ventricular assist device

Publication Link

https://pubmed.ncbi.nlm.nih.gov/27774271/

Study Completed

Cohort Name

Acute Heart Failure (AHF)

Cohort Size

Disease/Condition Studied

acute heart failure

Enrollment Time Window

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

patients on medical management, patients receiving implantable ventricular assist device

Patient Outcomes

managed medically or with ventricular assist device

Clinical Data Types Available

demographics, comorbidities, laboratory results, cardiac outputs, medication

Time Course Data Points

Day 1, 2, 3, 7, 30

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics