Data Entry Maintenance

Metadata Commons Identifier

HMC000050

Project Title

Diagnostic Biomarkers for Improved Heart Failure Management

Project Description

<p><span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 13px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">This project studied patients with two different types of heart failure - diastolic and systolic. These conditions have very similar presentations but different underlying causes, and require complex tests to diagnose. The objective of the study was to develop a simple blood test which would distinguish between the two forms of heart failure to aid in clinical management of patients. Heart failure patients have been enrolled and blood and urine samples were collected during clinic visits. The blood was analyzed for gene and protein levels to identify differences which could form the basis for a diagnostic blood test.</span></p>

Project Funder(s)

Mitacs, PROOF Centre of Excellence

Project Institution(s)

University of British Columbia, PROOF Centre of Excellence

Project Investigator(s)

Sean Virani, Mustafa Toma, Annemarie Kaan, Bruce McManus, Raymond Ng

Data Access Request URL*

Keywords

proteomics, transciptiomics, diastolic heart failure, systolic heart failure, preserved ejection fraction, reduced ejection fraction, biomarkers

Publication Link

Study Completed

Cohort Name

Diastolic heart failure (DHF)

Cohort Size

261

Disease/Condition Studied

systolic heart failure, diastolic heart failure

Enrollment Time Window

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

diastolic heart failure and systolic heart failure

Patient Outcomes

preserved ejection fraction, reduced ejection fraction

Clinical Data Types Available

Demographics, cardiac function, cardiac-related adverse events/hospitalizations, lab results, medication

Time Course Data Points

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics