Data Entry Maintenance

Metadata Commons Identifier

HMC000047

Project Title

Blood single-cell RNA sequencing of fibrotic interstitial lung disease subtypes

Project Description

<span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">Interstitial lung diseases (ILDs) are debilitating disorders that cause patients to slowly lose their lung function, resulting in shortness of breath, limited capacity for movement, and subsequent death. Over 4,000 British Columbians currently suffer from some form of ILD, yet not all of them receive proper therapy, partly due to difficulties in identifying the precise ILD subtype.<br style="box-sizing: border-box; outline-color: var(--ut-focus-outline-color,-webkit-focus-ring-color); clear: both; color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">A correct diagnosis is crucial to administering proper therapy, yet nearly half of ILD patients report a delay in diagnosis of more than one year, which delays optimal disease management and thus increases risk of death.<span style="box-sizing: border-box; outline-color: var(--ut-focus-outline-color,-webkit-focus-ring-color); color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">  <span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">Moreover, drug treatment for IPF costs ~$40k/year, whereas other ILD subtypes generally respond well to alternative medications that are ~90% cheaper. It is therefore critical that patients with ILD are diagnosed early and accurately to prompt initiation of effective therapy.<br style="box-sizing: border-box; outline-color: var(--ut-focus-outline-color,-webkit-focus-ring-color); clear: both; color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;"><span style="color: rgb(38, 38, 38); font-family: system-ui, -apple-system, 'system-ui', 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 14px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">To address the need for better ILD diagnosis, the goal of this project is to identify diagnostic cellular markers that can accurately distinguish between subtypes of ILD. This will be done by profiling gene expression patterns within individual white blood cells. There is considerable evidence that specific white blood cell populations are important drivers of ILD progression, which may explain prior unsuccessful attempts at identifying ILD subtype-specific markers in whole tissue specimens (i.e. lung, blood) rather than individual cells. Improving diagnosis will result in significant social and economic benefits and improve health outcomes for the thousands of patients suffering from ILDs.

Project Funder(s)

Genome British Columbia

Project Institution(s)

University of British Columbia

Project Investigator(s)

Christopher Ryerson, Scott Tebbutt

Data Access Request URL*

Keywords

interstitial lung disease, single cell sequencing, biomarkers

Publication Link

Study Completed

Cohort Name

SCAILD (single-cell analysis of interstitial lung disease)

Cohort Size

Disease/Condition Studied

interstitial lung disease

Enrollment Time Window

2021-2023

Biobanking Consent Available

Medical History Available

Ethnicity Availability

Time Course

Patient Phenotypes

fibrotic interstitial lung disease

Patient Outcomes

survival

Clinical Data Types Available

demographics, lung function, comorbidities, radiology, antigen reactivity, serology

Time Course Data Points

Enrollment City

Groups

Project

Cohort

Enrollment City

Groups

Samples and Omics